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Having assessed the relevance of the three C-terminal serine doublets on the phosphorylation of the receptor in response to agonist stimulation, we next investigated the effect of mutating each doublet to alanine on the capacity of the receptor to traffic to the plasma membrane and therefore be available for agonist binding, as well as its propensity to undergo agonist-induced endocytosis in INS-1 832/3 GLP-1R KO cells

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These medications were originally developed to manage diabetes

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