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Our results are consistent with those reported in previous studies demonstrating that GLP-1 agonists prevent excessive ECM degradation by suppressing cardiac fibroblast activity 61,62

doi: 10.1213/01.ane.0000269687.74660.45 241

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This broader mechanism may lead to greater metabolic effects and weight loss for some individuals, though dosing and response differ

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Details for tissue extraction, trypsin digestion, sample cleanup, and fractionation and liquid chromatographymass spectroscopy (LC-MS) analysis are described in Supplemental Methods