tirzepatide not hungry at all may only temporarily suppress brain 'food noise' activity** *by Perelman School of Medicine the University of Pennsylvania* A rare glimpse into the brain activity of a patient with obesity Lost 60lbs on Tirzepatide 😳

Recent research advancements indicate that the central nervous system symptoms associated with PEM, particularly fatigue and pain, can be conceptualized as interoceptive dysregulation. Interoception refers to the process by which the central nervous system perceives, interprets, and integrates internal physiological signals from the body (147)

A typical starting dose is 3.75mg/23mg once per day, which can be gradually increased to a maximum of 15mg/92mg per day

Birn H, Zhai X, Holm J, Hansen SI, Jacobsen C, Christensen EI, Moestrup SK

As a ghrelin mimetic, ipamorelin binds to ghrelin receptors in the pituitary gland and stimulates the release of an intermediary hormone, growth hormone stimulating hormone

Possible pathogenesis and prevention of long COVID: SARS-CoV-2-induced mitochondrial disorder

The activation of AP-1 leads to higher expression of two regulators (c-fos and c-jun) in cell proliferation and can lead to uncontrolled cell division