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Natural water sources like springs and wells often have slightly alkaline pH levels due to the presence of minerals like calcium and magnesium

Downie D, McFadyen MC, Rooney PH, Cruickshank ME, Parkin DE, Miller ID, et al

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Given the previously observed cardioprotective actions of GLP-1 in the absence of the GLP-1R, these data suggest that the ex vivo heart may not effectively metabolize GLP-1 to GLP-1(2836)