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Though the FDA approved it only for short-term use of less than 12 weeks, healthcare professionals often prescribe phentermine off-label for longer use

However, this does not inevitably lead to a loss of the biological function of these -defensins [147]

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This is more common in people with pre-existing digestive sensitivities, those taking high doses of other fiber supplements, or individuals whose baseline microbiome was significantly different from the profile Pendulum is trying to create