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This study used a nonparametric method (two-sided percentile: 2.5 th percentile to 97.5 th percentile) to determine the reference interval for serum GR, in accordance with the C28-A3 and WS/T 402-2024 guidelines [15, 16]

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3.2 RNS in IBD pathogenesis RNS comprise the second category of free radicals, produced as a byproduct of nitric oxide synthases(NOS) and expressed in specific intestinal submucosa and mucosal regions