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The answer lies in bioavailability , which refers to how much of a substance actually reaches your bloodstream and cells after you swallow it

Pest Manag Sci 70:13061315 Inupakutika MA, Sengupta S, Devireddy AR, Azad RK, Mittler R (2016) The evolution of reactive oxygen species metabolism

Catalase is abundant in peroxisomes

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The publication concluded that Supplementation with a combination of vitamin D and L-cysteine or glutathione precursor, rather than supplementation with vitamin D alone, is beneficial and helps achieve more successful vitamin D supplementation. Study Confirms Significant Effect of Vitamin D Level on Levels of Glutathione, GSSG, and Cysteine A study by Alvarez et al

The precise cause is multifactorial