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In Huntingtons disease (HD), oxidative stress plays a significant role in the neurodegenerative process

T., Sapin, H., Lee, C

Red blood cells carry oxygen to the brain and other organs, causing a lack of energy and depression without them

Cisplatin accumulates persistently in the mitochondria of energy metabolism-related organs (skeletal muscle, liver), forms platinum-mtDNA adducts to disrupt mitochondrial structure and function, and causes oxidative phosphorylation impairment and insufficient ATP production, ultimately driving persistent fatigue (Huot et al