PLoS Biology 2008;6, 2853-2868
Covalent crosslinks, single- and double-strand breaks, and disturbances in redox signaling can emerge from the oxidation and molecular damage that this causes to biological components such as lipids, proteins, and DNA (8, 138)
Pharmacologic approaches to glycemic treatment: Standards of Medical Care in Diabetes2019
Nausea, fatigue, and digestive issuesthe primary reasons patients stop medication-only programscan often be managed effectively with proper medical guidance and gradual dose adjustments
If progress slows, we adjust timing, titration, or activity rather than forcing a plateau
Further, these data suggest that by maintaining circulating triglycerides, GSH synthesis in the liver potentially supports fat stores in the body