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At therapeutic doses, GLP-1 drugs cross the blood-brain barrier and dampen dopamine signaling in the brains core reward center, making addictive substances less rewarding

Homogenates of liver or heart were made prepared at 10% (w v -1 ) in 0.1 mol L -1 Tris-HCl buffer, pH 7.4

Retatrutide activates three receptors simultaneously (GLP-1, GIP, glucagon) where semaglutide activates only one (GLP-1)

The correlation between reduced glutathione (GSH) levels and OSMs, such as MDA, is explored in studies

Magnesium : A study published in The Lancet found that magnesium supplements can improve muscle function and may help reduce the symptoms of conditions like hypertension and type 2 diabetes

The authors report no other conflicts of interest in this work