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Funding Open access funding provided by Department of Atomic Energy

Consistent absorption and systemic availability remain uncertain, and human pharmacokinetic data are lacking

Research indicates that GLP-1-associated weight loss follows this expected pattern

These actions are crucial for maintaining blood sugar levels and promoting satiety after meals

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copri is enriched in human OA patients yet beneficial in mouse modelsurgently requires intensive investigation in multiple aspects, such as strain-specific differences (e.g., metabolic function distinctions between pathogenic and beneficial strains), dynamic regulation of the host immune microenvironment (e.g., the effect of inflammatory status on the microbiotahost interaction), and the effect of environment in influencing the effects of metabolites (for example, the effect of regulation of gut niches and availability of nutrient substrate for the production of bioactive entities such as paraxanthine)