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Three approved maintenance doses: 5 mg, 10 mg, 15 mg

However, sustained overproduction of insulin exhausts the beta cells and cannot be maintained long term

With current cleavage strategies the chemical triggers can be divided into cathepsin-cleavable triggers, acid-cleavable triggers, GSH-cleavable triggers, Fe(II)-cleavable trigger, novel enzyme-cleavable triggers, photo-responsive-cleavable triggers, and bioorthogonal cleavable triggers (Table 1)

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