2021;16(7):e0251557
In 43 male workers from the cohort of 602 workers (section 8.5) (Thiess et al., 1981b), an increase in chromosomal aberration rate was found that was significant for the workers exposed for more than 20 years, but not for those accidentally exposed or exposed for average periods of 12 and 17 years (Thiess et al., 1981a)
Overall, we conclude that PC patients with low expression of VRK2 are sensitive to GSH-targeting therapy, while PC patients with high expression of VRK2 are re-sensitive to GSH-targeting therapy following VRK2 inhibition, indicating genetic aberrance of VRK2 expression stratifies the response of PC to metabolism-targeted therapies
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