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The incidences of major depressive disorder, anxiety, and suicidal ideations or attempts, as well as their hazard ratios, are higher in the GLP-1 RA group, indicating an association with GLP-1 RA treatment over time
Second, despite accounting for many relevant covariates in the adjustment and employing IPTW techniques, we may have missed some potentially relevant information and thus we cannot rule out residual confounding
doi: 10.1038/s41598-020-65269-6
The researchers concluded that most of these hormonal changes (particularly TSH and free T3) appeared to be independent of weight loss, suggesting a possible direct effect of semaglutide on thyroid regulation that still needs to be clarified, while changes in free T4 were more closely related to weight change
This project is supported by the National Cancer Institute (NCI) of the National Institutes of Health (NIH) under award number U01CA272541, which is part of the Metabolic Dysregulation and Cancer Risk Program (MeDOC) Consortium
2.8% at 24 weeks)
