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In the specific context of hearing and tinnitus, a conceptual link exists in the proposed brain-ear-heart axis, where neurotrophic factor supplementation to the cochlea could inhibit pathological protein aggregation and support neuronal health, potentially preventing conditions like AD and associated amyloid cardiomyopathy (Shityakov et al., 2021)

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In biochemical and cellular research systems, ipamorelin acts as an agonist at the ghrelin/growth hormone secretagogue receptor (GHSR-1a) expressed on pituitary somatotroph cells

BJU Int (e-pub ahead of print 10 January 2013