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Pathogenesis of PDN is poorly understood, but it is quite clear that hyperglycemia plays a vital role in the development of this diabetic complication
Semaglutide is a glucagon-like peptide-1 receptor agonist that works through the incretin system it enhances glucose-dependent insulin secretion, suppresses inappropriate glucagon release, and slows gastric emptying, with appetite effects mediated largely in the central nervous system
