The 50 and 130 kDa low-molecular-weight forms specifically produced significant wrinkle-depth reduction by mean roughness (Ra) and maximum roughness (Rz) measurement, attributed to deeper dermal penetration of the smaller molecules [7]
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Clinical biomarker data, including the association of circulating mitochondrial DNA with disease severity and pancreatic necrosis, further support the relevance of mitochondrial damage in patients, but again do not directly validate the structural and functional hierarchy of the inter-organellar network proposed from experimental studies (99)
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