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Regulatory agencies in some regions have issued warnings that these extreme, non-therapeutic doses can put undue stress on the kidneys and liver

Heme iron can generate various DNA-damaging factors, including reactive oxygen species (ROS), lipid peroxidation end-products, and NOCs, all of which contribute to DNA damage and gene mutations, key factors in the development of cancer

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ESM Tables 2 and 3 compare the baseline, demographic and clinical characteristics of the GLP-1RAs and metformin groups

2014): Benoist CC, Kawas LH, Zhu M, et al