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Mampre D, Spaide R, Mason S, Van Baalen M, Gibson CR, Mader TH, et al

Weight loss is not guaranteed and is influenced by many factors, including diet, exercise, and individual biology." The brand-reported "up to 25% body weight reduction" figure is a ceiling cited in the context of program-wide data, not a guarantee of individual outcomes

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Tesamorelin is FDA-approved for specific medical indications, while ipamorelin is usually evaluated based on provider assessment and patient-specific goals

However, certain medications can affect its efficacy