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Nat Chem Biol 16(5):497506

11 Alzheimers disease is a neurodegenerative disorder that is characterized by the formation of amyloid plaques, development of tau protein tangles, and neuroinflammation

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Information deriving from such disparate fields as earth and environmental sciences, biomedicine, biochemistry and chemical biology, physical chemistry is employed to the aim of building as comprehensive as possible framework to understand the toxic properties of the metals based on the unifying mechanism(s) of their interaction with biologically crucial thiolate ligands

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