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Subsequent applications of Ex-4c further depolarized the membrane potential in three of six cells (50%) by 5.10.8 mV (from 43.63.5 to 38.54.2 mV, n =3) (Fig

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Studies have demonstrated that endothelial NAD+ levels decrease by 40-60% during aging, correlating with reduced nitric oxide bioavailability and impaired vasodilation