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However, further study is needed to eliminate confounding factors

The uptake by the liver and kidneys is relatively low

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Levels greater than 3.7 mg/dL at 4872 hours post-ingestion have been reported as associated with higher mortality from acute liver failure

The DNA of eggs may be damaged, resulting in fertilization issues

Once the tumour became arrested in the palbociclib-treated group, mice were further randomized to receive either RSL3 (50 mg kg 1 , two times per week for 2 weeks) or the vehicle, resulting in four experimental groups: vehicle, RSL3, palbociclib and palbociclib + RSL3