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If this drug class is new to you, our primer on what GLP-1 medications are and how they work covers the fundamentals before the comparison details below

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Understanding how these hormones function naturally has prompted interest in whether dietary supplements or lifestyle interventions might support their endogenous production or activity

The estimated effects on blood glucose and body weight were largest in 2021, immediately after GLP-1s were included in the VHA formulary

Clinically Proven Results Clinical trials have consistently demonstrated the profound efficacy of GLP-1 RAs in achieving significant and sustained weight loss

The most common side effects are gastrointestinal: nausea, vomiting, diarrhea, constipation, abdominal discomfort, reduced appetite, and indigestion