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In this context, methylene blue is often associated with: Supporting mitochondrial efficiency Influencing ATP production inside cells Helping cells utilize oxygen more effectively Supporting brain energy metabolism Another reason it attracts attention is its potential antioxidant activity

Nat Rev Endocrinol 21(8):495509

2.3.2 Chronic inflammation-mediated suppression of BCAA metabolic enzymes Chronic low-grade inflammation serves as an important link connecting obesity, insulin resistance, and BCAA metabolic dysregulation

doi:10.1111/jdi.12094 36

The DHRS2 encoded enzyme is a member of the short-chain dehydrogenase/reductase (SDR) family of oxidoreductases