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FIGURE 5 3 Structural determinants of Neto2 binding to KARs Native KARs assemble into macromolecular complexes with the auxiliary subunits Neto1 and Neto2

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References (this section): NEJM (2023): Phase 2 trial publication Eli Lilly: Phase 2 results (mentions 24.2% at 48 weeks as a secondary endpoint) Eli Lilly (Dec 2025): Phase 3 TRIUMPH-4 topline results announcement Retatrutide side effects: what trials report (not medical advice) Searches like retatrutide side effects and side effects of retatrutide usually refer to events reported in clinical trial publications and sponsor summaries

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The Synergy: A 1+1+1 Effect When these compounds are used together, they create a synergistic effect that enhances cellular energy metabolism

Discard expired semaglutide and contact PlexusDx to request a replacement vial if you have remaining treatment days