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Oxidative stress develops when reactive oxygen species exceed antioxidant and repair capacity

Muscle contractile activity regulates Sirt3 protein expression in rat skeletal muscles

In addition, SCFAs also inhibit the activity of histone deacetylase (HDAC) and regulates gene expression to affect body health (He et al., 2020) (Figure 1)

Strikingly, the study revealed that the immune cells of these patients act as an "energy sink." In a desperate attempt to survive the overwhelming oxidative stress, the immune cells upregulate their own intracellular glutathione production

Overall mouse health was assessed by daily inspection for signs of discomfort, weight loss, or changes in behaviour, mobility, and feeding or drinking habits

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