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This localization theoretically reduces systemic side effects and cancer concerns compared to long-acting analogs, though local effects may still influence surrounding tissues

doi:10.1023/a:1022525214871 113. Siegel-Ramsay, J

Acknowledgements This research was funded by the Guangdong Provincial Department of Education as a scientific research project (2024KQNCX133), Zhanjiang Marine Youth Talent Project (2024R3004), the National Natural Science Foundation of China (82103834) and the Innovative Research Group of Functional Food Development and Quality Analysis (ZY24PYTD05)

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After two consecutive weeks of unilateral lower extremity immobilization, walking recovery, and resistance exercise interventions in healthy middle-aged men, a significant downregulation of PGC-1, mitochondrial fission process 1 (MTFP1), TFAM, and DRP1 mRNA levels was found, along with a slight decrease in NRF1 and MFN1 protein levels in the skeletal muscle tissue of middle-aged men during the period of unilateral lower extremity immobilization

n= 10 per treatment group