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Decreased GLP-1R and GIPR expression was observed in islets isolated from carriers of the type 2 diabetes risk allele of transcription factor 7 like 2 ( TCF7L2 ) (rs7903146) [21]

Glucagon Glucagon is a 29aa hormone that is produced by the preproglucagon gene

Exogenous GLP-1 RAs At normal physiological levels, active GLP-1 levels peak around 30-60 minutes after ingesting a meal before being rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4)

doi: 10.1038/304368a0 14 HansenLDeaconCFOrskovCHolstJJ

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