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This combination may not be appropriate if you: Have a history of pancreatitis Have severe kidney disease (metformin contraindicated) Are pregnant, breastfeeding, or planning pregnancy Have a history of medullary thyroid cancer or MEN 2 syndrome Cannot tolerate gastrointestinal side effects Side effects to watch for When taking Mounjaro with metformin, you may experience side effects from either medication

NAION is, unfortunately, permanent compared to other visual side effects like papillitis

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Maintaining weight loss can be a much larger challenge

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Purnell J, Zinman B, Brunzell J