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Jones MW, Lopez RA, Deppen JG

229 In addition, CARM1 methylates FOXO3, increasing its transcriptional activity and increasing the expression of atrophy-related genes such as Atrogin-1 and MuRF1 , thus connecting autophagy regulation to muscle degradation

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Prior studies have identified the insula as a key region implicated in smoking behavior and nicotine dependence (25, 26)