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Of particular interest is the study of the cleavage processes of axial Co- C, Co- N, and Co- O bonds [51, 60,61,62,63], by applying the DFT method [64,65,66,67,68] or the QM/MM method, in which the main part of the QM is again the DFT method [69,70,71,72,73], studying the biochemical mechanisms [74,75,76] with the participation of vitamin B12 cofactors [77,78,79,80]