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None of these have been validated in a published human randomized trial

This is a credibility limitation, not a safety verdict

The active folate pool includes 10-formyl-THF, 5,10-methenyl-THF, and 5,10-methylene-THF

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A large retrospective analysis of 237,043 patients with hip or knee OA, including 23,000 individuals exposed to GLP-1 agonists for at least 1 year, found that arthroplasty risk at 1 year was reduced by approximately 40% for hip replacement and 25% for knee replacement