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Statins bind to mammalian HMG-CoA reductase at nanomolar concentrations, leading to effective displacement of the natural substrate, HMG-CoA, which binds at micromolar concentrations (23)

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Such a study requires a drug which is practically specific for one condition whose prevalence is known, and the one which approximates most closely to this appears to be vitamin B12

doi: 10.1136/bmj.315.7109.629 29 HajeMNaoomK

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