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3e and f)

McDowell MA, Fryar CD, Ogden CL

Obesity/hyperleptinemic phenotype impairs structural and functional plasticity in the rat hippocampus

Additionally, patients in the SUSTAIN-6 trial were not randomized within the subgroup of interest, meaning that unmeasured confounders could bias the treatment effect estimate

Over a mean follow-up period of 2.4 years, 0.2% of the GLP-1 receptor agonist cohort progressed to wet AMD compared with only 0.1% of control participants, resulting in an increased hazard for wet AMD of 2.21 for the GLP-1 RA cohort