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In diabetic mice, semaglutide alleviated anxiety- and depression-like behaviors and improved cognitive performance via modulation of the microbiota-gut-brain axis ( In summary, accumulating evidence supports the potential of GLP-1RAs in treating neurodegenerative and psychosocial disorders

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Importantly, we confirmed that hepatocyte Cyp2e1 protein levels were significantly lower in the presence of GLP-1R agonism in both the control and ethanol consumption group (Fig