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Journal of Dermatological Science , 104(2), 67-78

Alcohol disrupts protein synthesis while tobacco compromises circulation and oxygen delivery to healing tissues

In addition, NAPQI also deactivates some of the enzymes that recycle GSH, such as GSH peroxidase

However, kidney function becomes critical when combining these medications, particularly metformin, which requires monitoring of glomerular filtration rate (eGFR)