observed two distinct populations of alpha-cells with similar proglucagon expression but differential expression of proliferation-associated genes (e.g., TOP2A , MKI67 , CENPF , BIRC5 , and CDK1 ), suggesting that one of these subpopulations, albeit the smaller subpopulation, of alpha-cells may constitute proliferating alpha-cells (71)
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But those drugs, known as GLP-1s, are also facing increased scrutiny after some patients reported experiencing stomach paralysis and suicidal ideation while taking them
Rapid urbanization, rising middle-class incomes, and increasing metabolic disease burden across China, India, Japan, and South Korea are accelerating demand
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The pore-forming claudin (CLDN)-2 and barrier forming CLDN-12 seem to be crucial in the Ca 2+ transport through tight junction proteins (17)