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Conversely, TMAO dose-dependently augmented ERK1/2 pathway activation and myofibroblast trans-differentiation, when co-administered with TGF-1 in comparison to TGF-1 or TMAO alone, without affecting SMAD3 phosphorylation (Fig

Furthermore, the convergence of herbal therapeutics with modern pharmacology presents an avenue for customized and integrative AD management

The lactylated MRE11 is more likely to bind to DNA, thereby promoting the phosphorylation of ATM, and ultimately facilitating the cutting and homologous recombination (HR) at the ends of DNA, mediating the chemoresistance of tumor cells

Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have emerged as promising therapeutic agents with potent anti-inflammatory properties and diverse clinical implications

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