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The transport of Cu/Zn in hepatocytes can be divided into three steps: (i) uptake, (ii) intracellular distribution, and (iii) utilization and export, which all may be facilitated by MTs

also anti-inflammatory Arbutin / alpha-arbutin : gentler tyrosinase inhibition, well-tolerated Melanin Dispersion / Cell Turnover Retinoids (tretinoin, retinol) : accelerate epidermal turnover to shed pigmented cells

Innovation will broaden choice: oral therapies, triple agonists, combination treatments and agents designed to improve tolerability will increase diversity and competition

Health Technol Assess (2005) 9(26):1134

Some products claim enhanced convenience, eliminating the need for multiple daily doses

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