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Description

Xie C, Zhong D, Chen X

In the SURPASS trials, once weekly tirzepatide (515 mg) significantly reduced HbA1c (1.873.02%) and improved several cardiometabolic risk factors

Later that year, however, a new observational study published in JAMA Network Open reignited the debate around the safety of the class, prompting the FDA to take another look

If the baseline risk of gallbladder disease is roughly 1% per year in the general population, tirzepatide might increase that to approximately 1.5% to 2%