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The decrease in metabolic capacity causes the accumulation of reactive E 2 metabolites, which further aggravate metabolic disorder (60)

In turn, the UK Medicines and Healthcare product Regulatory Agency (MHRA) and the UK multidisciplinary consensus statement guidance suggests that these drugs should be withheld the day before planned surgery [18, 39]

Given the lack of safety data, most clinicians recommend considering alternative weight management approaches during lactation

Previous studies have shown that selective depletion of synovial macrophages during experimental OA largely reduces cartilage damage and osteophyte formation, which are two major hallmarks of OA 48

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Daniela Hurtado Andrade, an endocrinologist at the Mayo Clinic in Jacksonville, Florida