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During ER stress, GRP78, the primary regulator of UPR, dissociates from the ER compartment, activating the main PERK protein pathway

Symptoms of vitamin B-12 deficiency include fatigue, weakness, and dizziness

neonates, and particularly preterm infants, lack the enzyme capacity to clear it, and accumulation causes the potentially fatal gasping syndrome first described in the New England Journal of Medicine report by Gershanik and colleagues

152 OlssonT.BarcellosL.AlfredssonL

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GPX4-independent antioxidant pathway Although the ER (endoplasmic reticulum) has been suggested as the primary site for the initiation of ferroptosis [126], various cellular compartments contribute to the ferroptosis process [127]