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[DOI] [PubMed] [Google Scholar] 36.Shi XL, Ye JP, Leonard SS, Ding M, Vallyathan V, Castranova V, Rojanasakul Y, Dong ZG

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Key priorities include doseresponse optimization for acute versus chronic phases, inclusion of biomarkers such as glutathione reductase activity, neuroinflammatory cytokines, and imaging-based lesion metrics, and development of formulations that improve central nervous system bioavailability