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10 IGF-1 and Cancer Risk (PubMed)Reviews of IGF-1 signalling and its association with proliferation and tumor growth

PubMed Carboni, L

The August 2023 announcement of topline results was followed in November 2023 by a presentation of detailed results 7 , which revealed a statistically significant reduction in non-fatal myocardial infarction of 28% and smaller reductions in cardiovascular death and non-fatal stroke which were not statistically significant over the length of the trial (up to five years)

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This overlap provides a biologically plausible framework through which GLP-1 signaling may help stabilize cellular energy regulation, particularly in the context of metabolic stress, even if direct effects on intrinsic aging processes remain to be fully established