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The foundational mechanism work was published by Szeto (2014) in British Journal of Pharmacology

These molecular changes correlated with improved sleep quality and normalized cortisol secretion patterns

He was also principal investigator in one of the nalmefene pivotal studies, investigator in the sodium oxybate trial and Spanish coordinator of the acamprosate trial (Adisa study)

In vivo , reductases recycle disulfides to thiols using cellular-reducing equivalents (e.g., NADH or NADPH) maintaining a favorable oxidoreductive (or redox) state in the cell and thiol conservation

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