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Given the similarities between the brain's and retina's vascular systems, these findings suggest that GLP-1R agonism could also protect the brain's microvasculature, preserving the integrity of the blood-brain barrier and improving cerebral blood flow

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To create the necessary energy deficit, patients are encouraged to target a daily reduction of 500750 kcal, typically achieved through an eating plan of 1,2001,500 kcal/day for women and 1,5001,800 kcal/day for men [133]

Published research protocols typically describe washout or clearance periods between compound administration

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