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Additional information Guang Li and Meng Yang contributed to the work equally and should be regarded as co-first authors

It is essential that culture conditions are optimized, so that NCs do not lose their characteristics

Researchers focusing on facial skin rejuvenation sometimes inject in the abdominal or upper arm areas nearest the face and neck

We utilize small-batch synthesis and rigorous quality control to ensure that the amino-acid sequence is exact and the final product is free from contaminants

The 2 mL example row is the volume that keeps draw amounts in an easy-to-measure range it is not a recommendation, since no human dose has been established

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