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Gene expression and phosphorylation of AANAT (the rate-limiting enzyme in melatonin synthesis) become downregulated

9,10 As well as gut hormones, bone remodelling is also known to be regulated by parathyroid hormone (PTH) and influenced by various other biochemical factors, such as calcitonin, oestrogen, thyroid hormones, glucocorticoids, insulin-like growth factors (IGFs), bone morphogenetic proteins (BMPs), prostaglandins, vitamin D, and transforming growth factor (TGF-), 4,11 but the focus of this report will primarily be gut hormones

Comparing Topical and Oral Approaches Different modalities work at different levels

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(4) study design: RCT published in full text

McGlashan TH, Hoffman RE