[1] Martello E et al
Activation of the NLRP3 inflammasome leads to the cleavage of procaspase-1 into its active form, which in turn processes proinflammatory cytokines such as IL-1 and IL-18 and drives pyroptotic cell death via Gasdermin D activation
iu ny gip ngn nga sm da, nm v cc du hiu lo ha sm do nh nng gy ra
Therefore, MB should be considered as an alternative drug in the treatment of malaria, especially in the context of the emergence and spread of drug-resistant Plasmodium species and strains across several countries (Marques et al., 2014
Interestingly, these extracts show enhanced effects in strengthening intracellular antioxidants like CAT, SOD, GSH, and GST to lower lipid peroxidation products MDA/TBARS, and reduce prominent pro-inflammatory markers like TNF-, 1L-, IL-6, MCP-1, COX-2, and nitric oxide synthase in these animal models
By acting as a natural calcium channel blocker, magnesium protects the mitochondria from the damaging effects of chronic inflammation and immune dysregulation, ensuring that these cellular powerhouses can continue to function even in the face of systemic illness
