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Administration of a recombinant adenovirus producing GLP-1 (4 10 9 PFU/mouse) to ob/ob mice reduced the macrophage population and production of TNF- , MCP-1, and IL-6 in adipose tissue via inhibition of nuclear factor-kappa B (NF- B) activation and phosphorylation of ERK1/2 and c-Jun N-terminal kinases [18]
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